The effect of nebivolol on atherogenesis in apoE-knockout mice.
نویسندگان
چکیده
Nebivolol is a novel beta1-blocker with a nitric oxide (NO)--potentiating, vasodilatory effect that is unique among beta-blockers. It was already shown that nebivolol ameliorates atherosclerosis in cholesterol-fed rabbits. We, therefore, wanted to investigate whether this is the case in the fine experimental model of atherosclerosis: apolipoprotein E (apoE)-knockout mice. Nebivolol attenuated atherogenesis, measured both by "en face" method (9.23+/-1.8% vs. 14.6+/-2.1%) and "cross-section" method (63125+/-8455 microm(2) vs. 91416+/-8357 m(2)). This is the first report showing the effect of nebivolol on atherogenesis in gene-targeted mice.
منابع مشابه
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ورودعنوان ژورنال:
- Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
دوره 60 4 شماره
صفحات -
تاریخ انتشار 2009